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Peterson and colleagues at rush university medical Center carried out an observational study of ICU patients' oral nutritional intake in the 7 days following extubation after mechanical ventilation for acute respiratory failure.
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This study sought to determine whether the coagulo-pathy associated with chronic liver disease specifically the elevated International Normalized Ratio (INR) frequently present in patients with advanced disease is protective against venous thromboembolism (VTE) in hospitalized patients.
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Difficult intubations are usually the result of a difficult airway, sometimes anticipated and sometimes not.
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As concerns grow over the expense and slow progress of classic randomized clinical trials (RCTs), an intriguing alternative is gaining steam adaptive design, in which trials change at various decision points in response to accumulated data.
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Internet research has been an issue for IRBs since its roots in the 1990s, and the challenges ethics boards face in reviewing such studies are in pioneer territory.
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Internet technology and its impact on society have evolved so quickly in recent years that researchers and IRBs lag far behind in their efforts to understand and use this new forum.
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For researchers and IRBs there is an ethical paradox in behavioral studies involving populations that are hard to engage.
